DBS
Template Main Javascript File


Groups


The RNP Biology Lab (RBL) members, are working in the following main themes

  • Understanding kidney tissue homeostasis, with special emphasis on epitranscriptomic modifications
  • Establishing Cellular models to understand podocyte biology
  • Collaborative project on modelling Kinase activity during stem cell differentiation.

  • 1. Swati Shree Padhy

    Post-Doctoral Research Fellow (May, 2021)

    swatis.padhi[AT]iiserbpr.ac.in

    I am a cancer biologist interested in understanding the molecular basis of tumorigenesis with special interest in genomic instability and DNA Damage Response in Head and Neck Squamous cell carcinoma. Understanding the molecular events to the process of genome instability in tumorigenesis of Oral Cancer will enable biomarker development and clinical management of the disease. The molecular pathological validation study with patient samples shows that β-catenin, a transcription factor, might be playing a vital role in regulating two very important pathways that are telomere maintenance and hTERT regulatory and stem cell maintenance pathway, known to be the hallmarks of tumorigenesis and responsible for the DNA Damage responses generated due to the progression of the carcinogenesis. I am interested in linking three distinct and important events in molecular carcinogenesis processes such as tumor development, dedifferentiation and genomic instability in Head and Neck Squamous cell carcinoma. Apart from research I am interested in music, dance and philosophy.




    2. Arushi Mishra

    Ph.D. Research Scholar (August, 2020)

    arushim[AT]iiserbpr.ac.in

    Until recent past, non-coding RNAs were considered to be “junk,” but gradually their involvement in various cellular processes like chromatin remodelling, transcription, alternative splicing and translational regulation was discovered, which are directly or indirectly involved in cancer development and progression. Thus, my major motive is to find out the role of microRNAs and other noncoding RNAs in Wilms’ tumor using various molecular methods. Along with this, I have a keen interest in Indian Classical music and dance (Kathak).




    3. Sourav Dey

    UGC-Junior Research Fellow (January, 2020)

    souravd19[AT]iiserbpr.ac.in

    Genetic information is converted into a functional product within the cell through a series of biological events. One such event is “Post Transcriptional Processing,” upon which diversification of genetic information relies, which can even cause alteration of Cellular Functions. Alternative Splicing, itself being a post transcriptional processing event, builds the diversification of gene expression by increasing the mRNA diversity. I am trying to understand the role of alternative splicing in various cellular aspects by studying a Protein - WTAP (Wilm’s Tumor-1 Associated Protein). This protein plays a role as a splicing and m6A RNA methylation regulator in post transcriptional processing and also acts as a regulatory protein in various cancers. So my ultimate goal is to find the link between post transcriptional processing and cancer development by studying WTAP.




    4. Ibakordor Khyriem

    MS Project Student (July 2021- Present)

    ibakordor17[AT]iiserbpr.ac.in

    I am interested in cell biology and understanding the intricacies and mechanisms that control growth, differentiation, transformation and function of these entities that make up whole organisms.
    m6A modification is an RNA methylation mark that has been studied the most, m6A appears to be a dynamic modification. FTO is a protein responsible for removing these marks from RNA and is found to be associated with several health conditions. Currently I am trying to study the role of FTO in mESCs by looking into the cellular and molecular mechanisms and characterizing FTOko mESCs. I am also trying to find out if there are similar proteins or protein domains that perform the same role of m6A erasers in Drosophila melanogaster using bioinformatics.
    Also a little bit about me, I like to cook, bake and sing when I’m not working in the lab.




    5. Aiendrila Roy

    MS Project Student (Nov. 2020 - Present)

    aiendrila16[AT]iiserbpr.ac.in

    I am interested in neuroscience.My inclination towards neuroscience has always been plastic and traversed through its various aspects. Currently I am trying to understand the role of mammalian m6A demethylase FTO in embryonic stem cell based neurogenesis.




    6. Iwin Joseph

    MS Project Student (Nov. 2020 - Present)

    iwin.16[AT]iiserbpr.ac.in

    I am interested in systems biology. My masters thesis work is related to understanding WT1 (Wilms tumour) protein-protein interactions using protein interaction network analysis. I am particularly focused on the difference in interactions of WT1 +KTS and -KTS isoforms. My hobbies include reading, coding and cycling.




    7. Arshida M M

    MS Project Student (Nov. 2020 - Present)

    arshida16[AT]iiserbpr.ac.in

    My interest is cancer biology. Currently, I am working on the role of mammalian mRNA-m6A(N6-methyladenosine) methylation erasers FTO (fat mass and obesity associated protein) and ALKBH5 (alkB homolog 5) in tumor stress responses, and the upstream regulators of these responses, with a focus on hypoxia response of renal cancer cell line.




    8. Priyanka Das

    MS Project Student (Nov. 2020 - Present)

    priyanka16[AT]iiserbpr.ac.in

    I am trying to understand how single nucleotide polymorphisms (SNPs) of m6A demethylase FTO associated with various disorders affect various cellular properties of breast cancer cell line MDAMB 468. I am also interested in understanding if the SNPs have impaired enzymatic activity.