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Patents


  • Title of the Invention: Polyhydroxy Derivatives Of [2,3,7,8-Tetrahydroxyl(1) Benzopyrano(5,4,3,(DE)(1)Benzopyran 5,10-Dione) as A Novel, Specific Inhibitors of Histone Methyltransferase (Hmtase) and Its Uses Thereof Inventors: Kundu TK, Selvi BR, Kishore AH, Mantelingu K Application filed: India (No.1090/CHE/2006, filed on 27/6/2006) International Patent Application (No. PCT/IN2007/000258, filed on 26/6/2007) PCT title: Site-specific inhibitors of histone methyltransferase (HMTase) and process of preparation thereof. US Patent No. 7,875,741, Granted on 25 Jan 2011

  • Title of the Invention: Intrinscially Fluorescent Carbon Nanospheres And A Process Thereof Inventors: Kundu TK, Eswaramoorthy M, Selvi BR, Dinesh Jagadeesan Application filed: India (No.2218/CHE/2007, filed on 3/10/2007) International Patent Application (No. PCT/IN2008/000632 filed on 30/09/2008 US Patent No. 9,034,387 granted on 19 May 2015

  • Publications


  • Bharathavikru R and Hastie ND (2018). Overgrowth Syndromes and Paediatric Cancers: how many roads lead to IGF2? Genes Dev 32:993-995.

  • Bharathavikru R*, Dudnakova T*, Aitken S, Slight J, Artibani M, Hohenstein P, Tollervey D, Hastie ND. (2017) Transcription factor, Wilms Tumour 1 regulates developmental RNAs through 3’ UTR interaction. Genes Dev 31:347-352.

  • Aitken S, Bharathavikru R. (2016). Bioinformatic Analysis of Next-Generation Sequencing Data to Identify WT1-Associated Differential Gene and Isoform Expression. Methods Mol Biol. 1467:211-219. (The Wilms’ Tumor (WT1) Gene (Humana Press)) Ed: Nicholas Hastie.

  • Selvi BR*, Swaminathan A*, Maheshwari U, Nagabhushana A, Mishra RK, Kundu TK (2015). CARM1 regulates astroglial lineage through transcriptional regulation of Nanog and posttranscriptional regulation by miR92a. Mol Biol Cell 26:316-26.

  • Chatterjee S, Mizar P, Cassel R, Neidl R, Selvi BR, Mohankrishna DV, Vedamurthy BM, Schneider A, Bousiges O, Mathis C, Cassel JC, Eswaramoorthy M, Kundu TK, Boutillier AL (2013). A novel activator of CBP/p300 acetyltransferases promotes neurogenesis and extends memory duration in adult mice. J Neurosci. 33:10698- 10712.

  • Selvi BR, Mohan Krishna DV and Kundu TK (2011). Modulating histone acetylation with inhibitors and activators. Epigenomics and Diseases (Cambridge Press) 379-388.

  • Selvi BR, Batta K, Kishore HA, Mantelingu K, Varier RA, Balasubramanyam K, Pradhan S K, Dasgupta D, Sriram S, Agrawal S, Kundu T K. (2010) Identification of a novel inhibitor of CARM1 mediated methylation of histone H3R17. J Biol Chem.
  • 285:7143-7152.

  • Selvi BR and Kundu TK. (2009) Reversible acetylation of Chromatin: Implication in regulation of gene expression, disease and therapeutics. Biotechnol J. 4:375 – 390.

  • Selvi BR*, S Pradhan*, J Shandilya, C Das, B S Sailaja, G Nagashankar, S Gadad, A Reddy, D Dasgupta and Kundu TK. (2009), Putative anticancer therapeutic, Sanguinarine interacts with chromatin; modulates epigenetic modifications and chromatin transcription. Chem Biol 16:203-216.

  • Selvi BR*, Jagadeesan D*, Suma BS, Nagashankar G, Arif M, Balasubramanyam K, Eswaramoorthy M, and Kundu TK. (2008) Intrinsically Fluorescent Carbon Nanospheres as a Nuclear Targeting Vector: Delivery of Membrane-Impermeable Molecule to Modulate Gene Expression In Vivo, Nano lett 8:3182-3188.

  • Kumar GV, Selvi BR, Kishore AH, Kundu TK, Narayana C. (2008) Surface enhanced Raman spectroscopic studies of coactivator-associated arginine methyltransferase 1. J Phys Chem B 112:6703-6707.